“Antibiotics of the Future” – Wall Street Journal, 16 December 2013

Misuse of antibiotics in people and livestock is rampant, and has caused the formation of antibiotic-resistant germs to speed up. As a result, scientists are trying to create new antibiotics that will fight the germs that existing antibiotics can’t fight.

Scientists are using varying methods to develop new antibiotics, such as adding silver, which can increase the antibiotics’ ability to combat germs. Researchers are also employing the bacteria’s own genetic sequencing to accelerate the creation of more powerful drugs.

In the US, almost two million people are infected yearly by antibiotic-resistant bacteria, resulting in thousands of deaths. It’s natural for antibiotics to become less efficient over time: bacteria develops a resistance, which means new antibiotics need to be created regularly. Both misuse of antibiotics and a decline in antibiotic development since 1990 have added fuel to the fire.

Researchers now have the capability to develop new antibiotics by studying germs’ genomes and looking for certain gene patterns. Most antibiotics are cultivated from the bacteria’s toxins—analyzing a germs’ genes has proven to be a great, albeit slow, method to creating new antibiotics.

Researchers are also looking for ways to render germs powerless. A person becomes infected when the bacteria’s population grows to a certain amount; scientists are trying to figure out if there’s a way to break communication between the individual microbes. In addition, scientists are trying to subdue toxins and other signaling molecules that are fundamental for an infection to advance.

February 28, 2014

Fluid Management Systems

Copyright 2014   All rights Reserved by Fluid Management Systems, Inc.

www.fluidmanagementsystem.com     subodh@fluidmanagementsystem.com

Social Share Toolbar

“What We can Learn from Our Microbiome” – New York Times, 19 May 2013

While it’s common knowledge that we inherit our genes from our parents — a.k.a. our “first genome” — our “second genome” is rarely talked about. This ‘second genome’ is the trillions of microbes that are living in our bodies, everywhere from our skin, to tongue, to intestines. These microbes have an immense impact on our health, perhaps even greater than the genes from our parents. For instance, our microbes act as managers for our immune systems, and are partially responsible for ascertaining between the good and bad that enter our bodies. Interestingly enough, while we can’t do much to change what our parents gave us, we can have a great influence on our microbiota and microbiomes.

Scientists look at our microbriota as ecosystems: all our microbes interact with each other and their environment. Disorders within this ecosystem – such as too little diversity or an excessive amount of the “wrong” type of microbes — have the potential to cause obesity, chronic diseases and other infections. Scientists also believe that diet and environment have led to an increase in autoimmune diseases in the West.

The American Gut Project’s aim is to sequence as many American guts as possible, hoping to answer the question of what effects our microbiota — diet, antibiotics, pathogens, environment, cultural traditions? — and determine its “normal” state, if there even is one.

While scientists can’t really say what a “healthy” microbiome looks like, they can pinpoint certain traits and patterns that healthier microbiomes have. Possessing a diverse set of microbes is better and something Westerners don’t necessarily have, due to processed foods, environmental toxins and overuse of antibiotics. Certain ailments and diseases, such as allergies, asthma, Type 2 diabetes and cardiovascular disease, plague the West more than less-industrialized areas. Your microbiota like unprocessed foods — less processed foods have a better chance of getting through the gastrointestinal tract and to the microbiota.

Children in the West are given an average of 10-20 antibiotic treatments before the age of 18; and this isn’t the only way antimicrobials are reaching the microbiota: antibiotics exist in meat, milk and surface water. Farmers feed antibiotics to their livestock so that they gain weight, and they often come in the form of medicated feed and water.

There are some things microbiologists suggest that can help with managing you and your children’s microbiomes:

  1. Don’t immediately jump to antibiotic treatments unless medically necessary.
  2. Cleanliness is not always next to godliness: take your children outside to play in the dirt more often.
  3. Cut back on processed foods.
  4. Eat more foods that contain probiotic bacteria: yogurt, kimchi and sauerkraut are good starting points.
  5. While you should still wash produce that is likely to have pesticide residue, you should, for example, not wash your hands after petting your dog or cat.

In other words, the world will be a more sustainable place to live healthy and happy  lifestyles if people in developed nations adapt some of the habits of their ancestors, as practiced today in developing nations. We do not have to worry about people in developing nations adapting habits of developed nations — it is already happening rapidly!

See our other entries:
Antibiotics and the Meat We Eat
Study Shows Bacteria Moves From Animals to Humans
Antibiotic-Resistant Bacteria Surround Big Swine Farms in China & US

Conceived, Developed and Written by Dr. Subodh Das and Tara Mahadevan

May 22, 2013

Fluid Management Systems

Copyright 2013   All rights Reserved by Fluid Management Systems, Inc.

www.fluidmanagementsystem.com     subodh@fluidmanagementsystem.com

Social Share Toolbar