“Antibiotics of the Future” – Wall Street Journal, 16 December 2013

Misuse of antibiotics in people and livestock is rampant, and has caused the formation of antibiotic-resistant germs to speed up. As a result, scientists are trying to create new antibiotics that will fight the germs that existing antibiotics can’t fight.

Scientists are using varying methods to develop new antibiotics, such as adding silver, which can increase the antibiotics’ ability to combat germs. Researchers are also employing the bacteria’s own genetic sequencing to accelerate the creation of more powerful drugs.

In the US, almost two million people are infected yearly by antibiotic-resistant bacteria, resulting in thousands of deaths. It’s natural for antibiotics to become less efficient over time: bacteria develops a resistance, which means new antibiotics need to be created regularly. Both misuse of antibiotics and a decline in antibiotic development since 1990 have added fuel to the fire.

Researchers now have the capability to develop new antibiotics by studying germs’ genomes and looking for certain gene patterns. Most antibiotics are cultivated from the bacteria’s toxins—analyzing a germs’ genes has proven to be a great, albeit slow, method to creating new antibiotics.

Researchers are also looking for ways to render germs powerless. A person becomes infected when the bacteria’s population grows to a certain amount; scientists are trying to figure out if there’s a way to break communication between the individual microbes. In addition, scientists are trying to subdue toxins and other signaling molecules that are fundamental for an infection to advance.

February 28, 2014

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NIAA Animal Disease Traceability Forum White Paper Released

The National Institute for Animal Agriculture (NIAA), an organization geared towards developing resolutions in different areas of the animal agriculture industry, recently released another White Paper, “Bringing Industry and Regulatory Leaders Together to Create Sensible Solutions”, a summary of the information offered at the Joint Strategy Forum on Animal Disease Traceability.

On December 20, 2012, the USDA introduced the Traceability for Livestock Moving Interstate rule, which was put into effect in March 11, 2013, and is a major element of the US’s Animal Disease Traceability (ADT) program, a system that identifies, tags and tracks livestock.

According to the USDA’s new rule, livestock transported between states, or interstate, must first be officially identified and carry an Interstate Certificate of Veterinary Inspection (ICVI) or other identification documentation, like owner-shipper statements or brand certificates. The law is pertinent to cattle, bison, poultry, sheep, goats, swine, captive cervids, and horses and other equine species that are transported interstate. Cattle less than 18 months old are not required to have documentation when crossing state lines, unless the animals are being used for shows, exhibits, rodeos or recreational events.

The USDA hopes to have all official ear tags with the official ear tag shield by March 11, 2014, and all official ear tags, that are on animals, to bear the shield.

The goal of the ADT program is to reduce the spread and impact of US animal and livestock diseases. If a disease outbreak occurs, then the program will assist the government in finding the source of the geographical location and diseased animal.

While it has been difficult ensuring that the ADT program is fully enacted, the USDA’s new ruling will enforce the tagging and tracking of animals and livestock.

Read our previous post on the NIAA’s Antimicrobial Use and Resistance White Paper.

September 9, 2013

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www.fluidmanagementsystem.com     subodh@fluidmanagementsystem.com

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“Mysterious Pork Virus May Hike Bacon Prices” – Fox Business, 7 August 2013

In June, we reported on the outbreak of a deadly pig virus that spread to 13 states, called Porcine Epidemic Diarrhea Virus (PEDV). With no known cure, the virus is continuing to proliferate across America, causing farmers to lose thousands of piglets. The good news is that the disease isn’t transferable to humans, and isn’t lethal for older pigs. The virus is also ongoing in countries like South Korea, China and Thailand — PEDV was first discovered in China in 2010.

In order to fight this disease that has yet to be cured, farmers are taking action to prevent the disease from growing; however, the loss of so many piglets may still give way to increased pricing.

As written in our previous post, PEDV is spread through fecal matter, specifically fecal-oral contact with manure; the infection can be spread by pigs eating diseased feces, or by humans unknowingly transporting feces. Pig farmers anxious to counteract PEDV are concentrating on sanitation, requiring clean supplies, and workers to wear clean boots and overalls. They’re also taking further measures, such as biosecurity plans and cleaning transport trucks with hot-steam pressure washers between shipments.

After a piglet is infected, it only takes 24-48 hours for virus to take full effect; a piglet can become sick within five days. Symptoms include diarrhea and vomiting — PEDV is fatal due to intense dehydration. The disease can infect older pigs, but, so far, has only been deadly for piglets.

Farmers haven’t been obligated to share the number of pig deaths at their farms; deaths may be underreported. Since the end of July, the USDA only knows of 403 PEDV-positive tests, but losses may range in the hundreds of thousands. The National Pork Board is spending $800,000 to investigate PEDV, and study methods for containment and removal.

As far as the cost of the disease go, farmers are likely to take a 7-8% hit to production — a farm could suffer a loss of over 1,000 piglets every week; PEDV has the potential to cost farmers $12-16 more per piglet. While our past harvesting season was abundant — grain prices are decreasing — the disease could definitely take its toll on pork prices.

Conceived, Developed and Written by Dr. Subodh Das and Tara Mahadevan

August 26, 2013

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Fluid Management Systems Granted Utility Patent

photo 4On June 18th, the US Patent and Trademark Office (USPTO) granted FMS a utility patent for a system that manages inventory through a non-invasive measurement process. USPTO also approved a trademark — VETrak — for commercial applications. FMS has several pending provisional and utility patents for human- and animal-health applications.

The measurement system developed by FMS is envisioned as a system to track injectable medications administered in hospitals, clinics and doctors’ offices. The technology resulting from this vision is highly adaptable; the first iteration of the technology will be implemented in the animal-health market.

photo 8

FMS is currently employing commercial VETrack units at swine farms in Illinois and Iowa. FMS is also in discussions with Lexington-based equine and pharma-manufacturing companies to expand the technology’s applicability to additional animal farms, as well as the human-health field.

Conceived, Developed and Written by Dr. Subodh Das and Tara Mahadevan

July 19, 2013

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“Do antibiotics in animal feed pose a serious risk to human health?” – Medical Xpress, 10 July 2013

Medicated animal feed and water, and the risk they pose to humans, is still widely debated in the agriculture industry, as many are on opposing sides.

Though there are moves to create new antibiotics that would allow for less antibiotic resistance, medical experts suggest that scaling down on antibiotic use overall should be our first step. From 2009-2011, 72% of antimicrobials sold in the US were used to medicate water and animal feed. Such additives are regularly given to animals, in order to boost growth and curb disease, and are often unnecessary since livestock are typically healthy; livestock living conditions — sometimes crowded and unhygienic — are what can encourage disease.

In April, we wrote about a new study by Britain and Denmark that showed that bacteria does indeed move from animals to humans. Denmark, the global forerunner in pork exports, seems to be an expert in the arena of antimicrobial use in livestock production: in 1994, Denmark decreased its usage of antimicrobials by 60%, while also expanding its pork production by 30%. From the British and Danish study, we can easily glean that regular antibiotic use in livestock production can breed resistance.

Politics also play a heavy hand in this debate, and contribute to an unwillingness to act.

See our previous blogs on this subject:
Antibiotics and the Meat We Eat
Study Shows Bacteria Moves From Animals to Humans
Antibiotic-Resistant Bacteria Surround Big Swine Farms in China & US

Conceived, Developed and Written by Dr. Subodh Das and Tara Mahadevan

July 11, 2013

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“Outbreak of deadly piglet virus spreads to 13 states” – NBC News, 19 June 2013

A new swine virus has been discovered in the US, the Porcine Epidemic Diarrhea Virus (PEDV), and has spread to 13 states, with over 100 positive cases. The virus was initially discovered in May, and has proved difficult to control, even in the summer heat. The spread of typical strains of gastroenteritis usually slow during the warmer months, but this strain of PEDV has proved to be quite resilient.

The disease has a high mortality rate with piglets — 50% — though the mortality rate has reached 100% in some areas. US PEDV is 99.4% identical in genetic structure to the Chinese PEDV that ravaged farms across China in 2010, killing over 1 million piglets. PEDV has been observed in many farming states, including Arkansas, Kansas, Pennsylvania, Colorado, Illinois, Indiana, Iowa, Michigan, Minnesota, Missouri, Ohio, Oklahoma and South Dakota.

This infectious outbreak could become even more deadly for the pork industry, which is still suffering from last year’s drought: the drought caused feed-grain prices to skyrocket, compelling farmers to slaughter more pigs than normal. Now there will be a scarcity for meat, with the possibility of pork prices soaring as well.

The USDA is still unsure of how PEDV entered the US — the current focus is the livestock transportation system. The USDA also thinks that the infection could have been spread by pigs eating diseased feces, or humans unknowingly transporting feces.

However, PEDV poses no threat to humans or other animals — it is safe for people to eat meat from pigs infected with PEDV.

Conceived, Developed and Written by Dr. Subodh Das and Tara Mahadevan

June 21, 2013

Fluid Management Systems

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“Drug Makers’ Push into Injectables Could Ease Shortages” – Wall Street Journal, 26 March 2013

Healthcare and drug companies are looking to join a market largely held by hospitals: injectable drugs, a $7 billion industry that often experiences shortages.

Drug mogul Becton Dickinson (BD), for example, plans on introducing 20-30 new injectable medicines to the US over the next few years, some of which have been in short supply. International drug companies are also seizing the market. Jordan-based Hikma Pharmaceuticals will launch 5-10 products in the next few years, also introducing a few of which have been scarce.

Companies like BD are attracted to this market because of the supply issue; and while sterilizing injectable drugs can prove difficult, the payoff is big: almost one billion vials  are sold each year. However, companies might have to wait for the long-run, as producing sterile medicines can be expensive with low profits. Many companies left the market due to the cost, leaving some drugs to just one manufacturer. In addition, manufacturing problems, supply constraints and government investigation of manufacturing plants have pushed many drug firms to abandon facilities or slow down production.

What resulted was an even larger shortage in 2011: 183, as opposed to 23 five years earlier. According to the FDA, the shortages fell to 84 in 2012, partly because Pfizer began manufacturing limited cancer injectables and some plants, which were previously shut down, reopened.

Yet, in order to turn a profit, many companies are looking into raising prices by 10%. This would greatly affect hospitals and their drug buyers, who will most likely fight the increases. In order to cut costs and availability, drug companies should consider  producing and selling drugs in multi-dose vials. Fluid Management Systems, Inc. has the technology to manage and monitor injectable drug inventories in multi-dose vials.

Conceived, Developed and Written by Dr. Subodh Das and Tara Mahadevan

April 10, 2013

Fluid Management Systems

Copyright 2013   All rights Reserved by Fluid Management Systems, Inc.

www.fluidmanagementsystem.com     subodh@fluidmanagementsystem.com

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