“Antibiotics of the Future” – Wall Street Journal, 16 December 2013

Misuse of antibiotics in people and livestock is rampant, and has caused the formation of antibiotic-resistant germs to speed up. As a result, scientists are trying to create new antibiotics that will fight the germs that existing antibiotics can’t fight.

Scientists are using varying methods to develop new antibiotics, such as adding silver, which can increase the antibiotics’ ability to combat germs. Researchers are also employing the bacteria’s own genetic sequencing to accelerate the creation of more powerful drugs.

In the US, almost two million people are infected yearly by antibiotic-resistant bacteria, resulting in thousands of deaths. It’s natural for antibiotics to become less efficient over time: bacteria develops a resistance, which means new antibiotics need to be created regularly. Both misuse of antibiotics and a decline in antibiotic development since 1990 have added fuel to the fire.

Researchers now have the capability to develop new antibiotics by studying germs’ genomes and looking for certain gene patterns. Most antibiotics are cultivated from the bacteria’s toxins—analyzing a germs’ genes has proven to be a great, albeit slow, method to creating new antibiotics.

Researchers are also looking for ways to render germs powerless. A person becomes infected when the bacteria’s population grows to a certain amount; scientists are trying to figure out if there’s a way to break communication between the individual microbes. In addition, scientists are trying to subdue toxins and other signaling molecules that are fundamental for an infection to advance.

February 28, 2014

Fluid Management Systems

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Bridging the Gap between Animal Health and Human Health — NIAA Antibiotic Symposium White Paper Released

The National Institute for Animal Agriculture (NIAA) recently published a white paper for the 2013 symposium, Bridging the Gap between Animal Health and Human Health, a continuation and extension of two previous symposiums, Antibiotic Use in Food Animals: A Dialogue for a Common Purpose in 2011 and A One Health Approach to Antimicrobial Use & Resistance: A Dialogue for a Common Purpose in 2012.

The goals of the 2013 and the past symposiums have been the same, supportive of the NIAA’s mission to continue forging a new path for a strong relationship between farmers, veterinarians, experts, drug companies and others, in order to resolve antibiotic resistance.

Twenty presentations were given by a range of experts on antibiotic use and resistance, which addressed many items, including the following:

  1. Due to wide mistreatment of antibiotics and a wide array of viewpoints, our knowledge of antibiotic resistance requires further study and clarification. There are many facets to antimicrobial resistance; if you believe you have a 100% understanding, then you haven’t received an accurate explanation.
  2. The relationship between animal, human and environmental health is compelled by the following: 1) the fact that antimicrobial resistance is bound to happen—its existence is natural and present, regardless of the use of antimicrobials; 2) when an antibiotic gains access to the ecosystem, there is a possibility that it will advance antibiotic resistance.
  3. Antibiotic resistance can be transferred between animals and humans, and vice versa.
  4. Antibiotic resistance is present in livestock, humans and companion animals, or pets.
  5. Antibiotic resistance is a global issue, not just an issue in the US.
  6. Meat manufacturing needs to follow current regulations, including correcting our mistreatment of animal antibiotics.
  7. Working towards decreasing the prevalence of antibiotic resistance requires collaboration. We must ask ourselves, “How does human health, environmental health and animal health work together to address antibiotic use and resistance?”.
  8. And much more.

(source)

Though the symposium brought key experts in human and veterinary medicine together to debate on the best approach to solving antibiotic resistance, there is still much to be done. We must closely observe and gain a better understanding of antibiotic resistance, as well as improve the motivation for advancing new antibiotics. Antibiotic resistance doesn’t originate from one source; the best way to focus on the issue is to streamline the system and eradicate any confusion.

Read all our blog posts on Human-Animal Health

Read the Bridging the Gap between Animal Health and Human Health White Paper

January 28, 2014

Fluid Management Systems

Copyright 2014   All rights Reserved by Fluid Management Systems, Inc.

www.fluidmanagementsystem.com     subodh@fluidmanagementsystem.com

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“Meat Industry Won’t Fight Antibiotics Rule” – Wall Street Journal, 12 December 2013

Last week, the FDA introduced new policy that aims to curtail growth promotion antibiotics used on livestock. The use of these antibiotics on animals has been linked to the generation of antibiotic-resistant bacteria in humans.

While farmers and the meat industry support the FDA, neither think the new regulations will have an impact on the livestock industry. The FDA’s regulations deem it illegal to use antibiotics for growth promotion purposes, only allowing for antibiotic use when medically necessary. While the FDA now requires veterinarians to supervise antibiotic use on livestock, farmers will still be able to use antibiotics for preventative measures, especially in feed and water.

According to the FDA, almost 30 million pounds of antibiotics were used on livestock in 2011, a 2% increase from 2010. In 2011, around 7.3 million pounds of antibiotics were used to medicate people.

The FDA’s new policy is not mandatory for drug companies, yet animal drug companies like Zoetis and Elanco have complied. The guidelines request that drug companies remove any wording from their labels that implies that a drug promotes growth.

These are the steps in the right direction to protect animal and human health while enhancing public image for livestock and drug companies.

December 27, 2013

Fluid Management Systems

Copyright 2013   All rights Reserved by Fluid Management Systems, Inc.

www.fluidmanagementsystem.com     subodh@fluidmanagementsystem.com

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